Non-cultured melanocyte transplantation for treatment of stable leucoderma: Experiences of an Australian centre

Leucodermas such as vitiligo, Piebaldism and post inflammatory hypopigmentation can have a significant psychosocial impact due to their cosmetically disfiguring and stigmatising characteristics. Though medical treatment and phototherapy have previously been considered the standard of care in these conditions, many of the patients are left with only partial or no repigmentation post treatment,1 Non cultured melanocyte transfer, although new to Australia, has been accepted as a standard of care throughout Asia, the Indian subcontinent and Europe in the treatment of leucoderma of various aetiologies. In the presence of stable disease and correct patient selection, repigmentation of greater than 80% has been shown to occur in more than 80% of patients.2 We review the current advances and future potential of non-cultured melanocyte transfer and present the experiences and challenges of introducing this technique within an Australian dermatological teaching centre.
1. Wassef C, Lombardi A, Khokher S, et al. : Vitiligo surgical, laser, and alternative therapies: a review and case series. J Drugs Dermatol. 2013;12(6):685–91.
2. Van Geel, N., Goh, B. K., Wallaeys, E., De Keyser, S., & Lambert, J. (2011). A Review of Non-cultured Epidermal Cellular Grafting in Vitiligo. Journal of Cutaneous and Aesthetic Surgery, 4(1), 17–22.

Dr. Nishant Valecha