Cytocidal effect of water-filtered broad-spectrum near-infrared on cancer cells

Background: Water-filtered broad-spectrum near-infrared has various biological effects including stimulation of collagen production, long-lasting vasodilation, and relaxation of dystonic and hypertrophic muscles, etc. Recently we developed anticancer therapy using water-filtered broad-spectrum near-infrared (1000-1800 nm) treatments and showed that it was equally or more effective than chemotherapy, because in vivo tumor apoptosis was markedly observed in near-infrared-treated tumors. The objective of this study was to investigate the most effective near-infrared wavelengths for anti-cancer therapy.
Methods: Near-infrared device emits broad spectrum 1000-1800 nm near-infrared together with a water-filter that excludes wavelengths 1400-1500 nm (Titan; Cutera, Brisbane, CA, USA) was used. The wavelengths of the near-infrared device were divided into 2 bands (1000-1200nm and 1500-1800nm) using optical filters. Proliferative activity of cultured cancer cell was evaluated by MTS assay.
Results: The wavelengths of 1500-1800nm as well as 1000-1800 nm significantly suppressed proliferation of various types of cancer cell lines. Twenty shots at 10 J/cm2 and 10 shots at 20 J/cm2achieved significant reduction in cell numbers. Significant difference was not observed between the control and the near-infrared treated group by 1000-1200nm.
Conclusions: We indicated that both 1500-1800nm and 1000-1800 nm near-infrared had anti-proliferative effects on cultured cancer cells. The near-infrared can be easily administered, regulated and precisely delivered only to the targeted areas, thus enabling us the induction of anti-cancer effects with a minimum level of discomfort and side effects. Water-filtered broad-spectrum near-infrared treatment with 1500-1800nm may be beneficial for treating various types of cancers.

Dr. Yohei Tanaka

Clinica Tanaka Plastic and Reconstructive Surgery and Anti-aging Center

As one of the leading Plastic Surgeons in Japan, Dr. Tanaka brings with him years of experience and a wealth of knowledge in the fields of Plastic and Reconstructive Surgery, anti-aging, and photobiology. He also possesses a deep understanding of and a well-established knowledge about energy based devices. As well as being the Founder of International Photobiological Society, he is also a member of many Japanese and international institutions and societies. Dr. Tanaka has published over 40 peer-reviewed papers in English on topics ranging from plastic and reconstructive surgery to cancer research in a number of prestigious international journals. Through intensive photobiological research, Dr. Tanaka discovered the various biological effects of water-filtered broad-spectrum near-infrared (1000-1800 nm together with a water-filter that excludes wavelengths 1400-1500 nm) including anti-cancer effects.