A case of granulomatous cheilitis in miescher-melkersson-rosenthal syndrome

Granulomatous cheilitis is a rare, chronic condition affecting the lips and perioral mucosa caused by granulomatous inflammation, and often associated with conditions such as sarcoidosis and Crohn’s disease, and can be seen in Miescher-Melkersson-Rosenthal syndrome(1). Miescher-Melkersson-Rosenthal syndrome comprises of granulomatous cheilitis, fissuring of the tongue, and facial nerve palsy(1). Treatment is difficult, and often involves the use of corticosteroids and anti-inflammatories(2). This case follows a young woman with intermittent upper lip swelling for 10 years through her clinical journey to find a diagnosis.

1. Savas J, Sokoloff D, Sanchez KM, Lichtstein DM. Granulomatous cheilitis: A stiff upper lip. Cutis. 2015;96(3):E18-20.
2. Banks T, Gada S. A comprehensive review of current treatments for granulomatous cheilitis. British Journal of Dermatology. 2012;166(5):934-7.

Dr. Nancy Huang