Treatment of cutaneous kaposi sarcoma with topical timolol

Kaposi sarcoma (KS) is a multifocal angioproliferative tumour associated with human herpesvirus 8 (HHV-8), or KS-associated herpesvirus (KSHV). We report a case of a 61-year-old man with iatrogenic KS affecting the left lower limb that developed in the setting of immunosuppression for a renal transplant. Despite treatment with radiotherapy, his hyperkeratotic lower limb lesions persisted, and were frequently ulcerated. He was treated with topical timolol maleate 0.5% gel three times daily, which resulted in a dramatic clinical response over the first three months, with no associated adverse effects. The observations from this case suggest that topical timolol may be useful for the treatment of superficial lesions in KS.

Miss Sonet Chap

Royal Brisbane and Womens Hospital

Dr Sonet Chap is currently doing her medical internship at the Royal Brisbane and Women's Hospital after graduating with a Doctor of Medicine from the University of Melbourne in 2016. Her interest in Dermatology developed during her research as part of her medical degree. In 2016, she undertook research at the Department of Dermatology, Royal Melbourne Hospital and laboratory-based work at the Drug Discovery Biology Laboratory, Monash Institute Pharmaceutical Sciences.