Red and sore in a rare patient

We report a novel case of relapsing lymphocytic panniculitis / clinically diagnosed Sweet’s syndrome in a 13 year old girl with Erdheim Chester disease treated with the BRAF inhibitor vemurafenib. Painful indurated lesions on the limbs and trunk were accompanied by rash and malaise which quickly resolved with cessation of treatment, oral steroids and / or nonsteroidal anti-inflammatories (NSAIDs) on various occasions. A summary of the literature is presented.
1. Choy B, Chou S, Anforth R, Fernández-Peñas P. Panniculitis in patients treated with BRAF inhibitors: a case series. Am J Dermatopathol. 2014 Jun;36(6):493-7.
2. Monfort JB, Pagès C, Schneider P, Neyns B, Comte C, Bagot M, Vignon-Pennamen MD, Viguier M, Lebbé C. Vemurafenib-induced neutrophilic panniculitis. Melanoma Res. 2012 Oct;22(5):399-401.

Dr. Ming Yan Lydia Chan

Auckland District Health Board - Dermatology Department

Graduating from the University of Auckland School of Medicine in 2008, Lydia Chan is the senior dermatology registrar at Auckland District Health Board. She has published and presented on teledermatology and various drug reactions. Next year she will be based in Australia for her overseas training requirement, aiming to further her interest in medical dermatology with a focus on hair and nail disorders.