Relationship between melanocytic naevi (MN) acquired during childhood and adult MN count and melanoma risk



Melanocytic nevus (MN) count is the major phenotypic risk-factor for melanoma. To determine if childhood MN counts predict adult MN counts, and to ascertain if recent sun-exposure influences MN development. Fifty-one Caucasian participants from Townsville (19.16°S), Australia were examined for MN aged 1-6 years, then re-examined Jan-June 2016, aged 21-30 years. Phenotype and MN were assessed clinically; demographic and sun-exposure information was documented using questionnaires. Incident MN count was positively correlated with childhood MN count (r=0.71, p<0.001). Fair-skinned participants, those with freckles, and those with poor tanning ability acquired more MN than olive-skinned participants (233 vs 53 MN, p=0.013), those without freckles (255 vs 99, p<0.0001), and those with a deep tan (233 vs 86, p=0.036).
Participants who averaged ≥5 hours outdoors/day in the previous year acquired more MN than those who spent ≤1 hour/day outdoors (216 vs 140, p=0.032). MN incidence rate increased with childhood MN count and sun-exposure. These results demonstrate those “at-risk” of melanoma from excessive MN can be identified prior to starting school, suggesting that interventions aimed at reducing sun-exposure should be introduced early to more effectively slow the acquisition rate of MN.


Dr. Ramez Barsoum

Princess Alexandra Hospital

Thank you for taking the time to read profile bios on the ACD ASM app! My name is Ramez, MBBS (Hons) 2016 with a very keen interest in clinical dermatology, particularly melanoma primary prevention strategies.

I also have a special interest in tele-health and mobile solutions for portable and accessible dermatoscopic solutions.

In this ASM, I am presenting an e-poster entitled "Relationship between melanocytic naevi (MN) acquired during childhood and adult MN count and melanoma risk."

Please feel free to contact me for any questions about the poster, the data we have collected or any other enquiries!

Email: ramez.barsoum@health.qld.gov.au
Mobile: 0411725228
Twitter: @drbarsoumr